Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.54 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.53 |
| ▸ | MPO | P05164 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | OGG1 | O15527 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9892966 | 0.96 | HDAC8 (0.71) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL7332673 | 0.95 | HDAC8 (0.69) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL18811605 | 0.87 | HDAC8 (0.59) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL32669061 | 0.84 | MAPT (0.60) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL26154128 | 0.81 | HDAC8 (0.60) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL9702868 | 0.79 | MAPT (1.00) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL9702876 | 0.79 | MAPT (1.00) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL28218859 | 0.79 | ALDH1A1 (0.45) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL27316749 | 0.79 | HDAC8 (0.62) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL9860574 | 0.78 | HDAC8 (0.60) | HDAC8HDAC6HDAC1HDAC3HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166040-A | Indole compounds | ELI LILLY AND COMPANY LIMITED (GB) | 2000-12-26 | — | — | US | disclosed |
| EP-0963983-A1 | Indol-2-ones as serotonin modulators | ELI LILLY AND COMPANY LIMITED (GB) | 1999-12-15 | — | — | EP | disclosed |
| WO-1999058525-A1 | INDOLE DERIVATIVES AS 5-HT2A LIGANDS AND AS SEROTONINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-11-18 | — | — | WO | disclosed |