Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.58 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.57 |
| ▸ | MPO | P05164 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | OGG1 | O15527 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332673 | 0.98 | HDAC8 (0.69) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL8132995 | 0.96 | HDAC8 (0.66) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL18811605 | 0.91 | HDAC8 (0.59) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL32669061 | 0.84 | MAPT (0.60) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL14880018 | 0.81 | HDAC6 (0.96) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL10283170 | 0.80 | HDAC8 (0.69) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL9702868 | 0.79 | MAPT (1.00) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL9702876 | 0.79 | MAPT (1.00) | HDAC8HDAC6HDAC1MAPTALDH1A1 | |
| SCHEMBL27868423 | 0.79 | NPC1 (0.68) | HDAC8HDAC6HDAC1ALDH1A1LMNA | |
| SCHEMBL17963141 | 0.79 | HDAC8 (0.61) | HDAC8HDAC6HDAC1DEGS1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| EP-3843844-A1 | COMPOUNDS | UCL Business Ltd (GB) | 2021-07-07 | — | — | EP | disclosed |
| US-20210171475-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2021-06-10 | — | — | US | disclosed |
| WO-2020043866-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2020-03-05 | — | — | WO | disclosed |
| US-20120142672-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | HDAC8 878/4885HDAC6 178/4885HDAC1 345/4885 |
| US-20210171475-A1 | COMPOUNDS | GOT2, GOT1, OAT | HDAC8 1247/4885HDAC6 186/4885HDAC1 525/4885 |
| US-20120142672-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | BACE1, APP, BACE2 | HDAC8 1912/4885HDAC6 699/4885HDAC1 1027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.