SCHEMBL8133012

SCHEMBL8133012

O=C1C[C@@](O)(C(=O)O)[C@H](C(=O)O)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRM8 O00222 1/20 0.30
GRM6 O15303 1/20 0.30
GRM2 Q14416 1/20 0.30
GRM3 Q14832 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6541949 1.00 GRM8 (0.30) GRM8GRM6GRM2GRM3
SCHEMBL11785262 1.00 GRM8 (0.30) GRM8GRM6GRM2GRM3
SCHEMBL4653448 1.00 GRM8 (0.30) GRM8GRM6GRM2GRM3
SCHEMBL6541931 1.00 GRM8 (0.30) GRM8GRM6GRM2GRM3
SCHEMBL7502610 0.71
SCHEMBL6543466 0.71
SCHEMBL8307214 0.71 LMNA (0.33)
SCHEMBL6542872 0.65
SCHEMBL8611928 0.58 TSHR (0.35)
SCHEMBL30803050 0.57 GRM2 (0.31) GRM8GRM6GRM2GRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11033597-B2 Dermatological kit comprising compositions based on hibiscus flower and buriti oil MEDICAL BRANDS RESEARCH B.V. (NL) 2021-06-15 US disclosed
EP-3203977-B1 DERMATOLOGICAL KIT COMPRISING COMPOSITIONS BASED ON HIBISCUS FLOWER AND BURITI OIL MEDICAL BRANDS RES B V (NL) 2018-12-12 EP disclosed
US-20170296613-A1 DERMATOLOGICAL KIT COMPRISING COMPOSITIONS BASED ON HIBISCUS FLOWER AND BURITI OIL MEDICAL BRANDS RESEARCH B.V. (NL) 2017-10-19 US disclosed
EP-3203977-A1 DERMATOLOGICAL KIT COMPRISING COMPOSITIONS BASED ON HIBISCUS FLOWER AND BURITI OIL Medical Brands Research B.V. (NL) 2017-08-16 EP disclosed
WO-2016055440-A1 DERMATOLOGICAL KIT COMPRISING COMPOSITIONS BASED ON HIBISCUS FLOWER AND BURITI OIL MEDICAL BRANDS RESEARCH B.V. (NL) 2016-04-14 WO disclosed
EP-3006016-A1 Dermatological kit comprising compositions based on Hibiscus flower and Buriti oil Medical Brands Research B.V. (NL) 2016-04-13 EP disclosed
US-6127553-A FROM THE LEAVES OF HIBISCUS FURCATUS, H. SABDARIFFA AND H. CANNABINUS, BY SOLVENT EXTRACTION WITH ACIDIC ALCOHOL, ADDING WATER TO EXTRACT TO REMOVE IMPURITIES, SUBJECTING FILTRATE TO FURTHER EXTRACTION, ESTERIFYING, HYDROLYZING; OPTICAL PURITY DEPARTMENT OF SCIENCE AND TECHNOLOGY, GOVERMENT OF INDIA (IN) 2000-10-03 US disclosed
US-6127553-A FROM THE LEAVES OF HIBISCUS FURCATUS, H. SABDARIFFA AND H. CANNABINUS, BY SOLVENT EXTRACTION WITH ACIDIC ALCOHOL, ADDING WATER TO EXTRACT TO REMOVE IMPURITIES, SUBJECTING FILTRATE TO FURTHER EXTRACTION, ESTERIFYING, HYDROLYZING; OPTICAL PURITY DEPARTMENT OF SCIENCE AND TECHNOLOGY, GOVERMENT OF INDIA (IN) 2000-10-03 US disclosed