Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083032 | 0.75 | CYP1A2 (0.47) | MAPTTSHRLMNACYP1A2CYP2A6 | |
| SCHEMBL3181838 | 0.72 | SLC22A2 (0.50) | MAPTRAB9ASLC22A2SLC22A1SLC22A3 | |
| SCHEMBL5467199 | 0.69 | MIF (0.41) | NPC1RAB9ATSHRLMNACYP1A2 | |
| SCHEMBL4396878 | 0.69 | NFE2L2 (0.44) | MAPTNPC1RAB9ASLC22A2SLC22A1 | |
| SCHEMBL20108650 | 0.65 | TYMP (0.42) | NPC1RAB9ANOS3TSHRLMNA | |
| SCHEMBL11404060 | 0.64 | NPC1 (0.53) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL11404058 | 0.64 | NPC1 (0.53) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL10387393 | 0.62 | MEN1 (0.43) | MAPTNPC1RAB9ALMNACYP1A2 | |
| SCHEMBL8155665 | 0.62 | TAAR1 (0.41) | TSHRLMNACYP1A2CYP2A6MEN1 | |
| SCHEMBL10816322 | 0.62 | RAB9A (0.43) | MAPTNPC1RAB9ASLC22A2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147080-A | PROTEIN KINASE INHIBITORS; ANTIPROLIFERATIVE AGENT | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-11-14 | — | — | US | disclosed |