SCHEMBL8133113

SCHEMBL8133113

CC(=O)c1csc2ccc(C#N)cc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.39
G6PD P11413 1/20 0.38
CYP2A6 P11509 1/20 0.37
MIF P14174 1/20 0.36
PPARA Q07869 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
HTR7 P34969 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HDAC9 Q9UKV0 1/20 0.34
HDAC5 Q9UQL6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8142788 0.81 GSK3B (0.47) DYRK1AG6PDCYP2A6MIFPPARA
SCHEMBL6230805 0.77 CYP2A6 (0.53) DYRK1ACYP2A6ALDH1A1MAPTHDAC3
SCHEMBL6598255 0.77 MAPT (0.46) CYP2A6ALDH1A1MAPTHDAC3HDAC4
SCHEMBL8290149 0.76 CYP2A6 (0.56) CYP2A6MAPTMAOB
SCHEMBL8561828 0.76 MTNR1A (0.54) DYRK1AMAPTHTR7HDAC3HDAC4
SCHEMBL8784829 0.75 CYP2A6 (0.55) G6PDCYP2A6MIFALDH1A1L3MBTL1
SCHEMBL20954564 0.74 ALDH1A1 (0.39) DYRK1AALDH1A1MAPTL3MBTL1STS
SCHEMBL8555827 0.73 MTNR1A (0.56) DYRK1AALDH1A1MAPTL3MBTL1MAOB
SCHEMBL31357903 0.73 CYP2A6 (0.43) G6PDCYP2A6MIFSTSMAOB
SCHEMBL10053318 0.73 CYP2A6 (0.43) G6PDCYP2A6MIFSTSMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0836606-B1 CONDENSED THIAZOLE DERIVATIVES, HAVING 5-HT RECEPTOR AFFINITY KNOLL AG (DE) 2000-08-30 EP disclosed
US-5869492-A TREATING CENTRAL NERVOUS SYSTEM DISORDERS KNOLL AKTIENGESELLSCHAFT (DE) 1999-02-09 US disclosed
EP-0836606-A1 CONDENSED THIAZOLE DERIVATIVES, HAVING 5-HT RECEPTOR AFFINITY KNOLL AKTIENGESELLSCHAFT (DE) 1998-04-22 EP disclosed
WO-1997002269-A1 CONDENSED THIAZOLE DERIVATIVES, HAVING 5-HT RECEPTOR AFFINITY KNOLL AKTIENGESELLSCHAFT (DE) 1997-01-23 WO disclosed