Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.45 |
| ▸ | SELE | P16581 | 2/20 | 0.45 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6130765 | 0.87 | MTNR1A (0.52) | MTNR1AMTNR1BALDH1A1HPGDMAPT | |
| SCHEMBL7206532 | 0.87 | ALDH1A1 (0.51) | MTNR1AMTNR1BALDH1A1HPGDCYP3A4 | |
| SCHEMBL9209256 | 0.82 | MTNR1A (0.48) | MTNR1AMTNR1BALDH1A1HPGDMAPK1 | |
| SCHEMBL11260725 | 0.80 | KDM4E (0.50) | MTNR1AMTNR1BALDH1A1HPGDMAPT | |
| SCHEMBL9220938 | 0.80 | MTNR1A (0.49) | MTNR1AMTNR1BHPGDICAM1SELE | |
| SCHEMBL1577696 | 0.80 | MTNR1A (0.49) | MTNR1AMTNR1BALDH1A1HPGDMAPT | |
| SCHEMBL7956785 | 0.79 | MTNR1A (0.51) | MTNR1AMTNR1BALDH1A1HPGDMAPT | |
| SCHEMBL9209251 | 0.79 | MTNR1A (0.45) | MTNR1AMTNR1BALDH1A1HPGDMAPK1 | |
| SCHEMBL10983401 | 0.79 | MTNR1A (0.45) | MTNR1AMTNR1BALDH1A1HPGDCYP3A4 | |
| SCHEMBL6598255 | 0.78 | MAPT (0.46) | ALDH1A1MAPTKDM4EMAOBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836606-A1 | CONDENSED THIAZOLE DERIVATIVES, HAVING 5-HT RECEPTOR AFFINITY | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002269-A1 | CONDENSED THIAZOLE DERIVATIVES, HAVING 5-HT RECEPTOR AFFINITY | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-01-23 | — | — | WO | disclosed |