Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 9/20 | 0.51 |
| ▸ | DRD2 | P14416 | 7/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494029 | 0.85 | FYN (0.51) | FYNDRD3DRD2DRD4MEN1 | |
| SCHEMBL7494035 | 0.85 | FYN (0.51) | FYNDRD3DRD2DRD4MEN1 | |
| SCHEMBL8124799 | 0.79 | DRD2 (0.56) | DRD3DRD2DRD4HTR1AADRB2 | |
| SCHEMBL9776784 | 0.79 | DRD2 (0.63) | FYNDRD3DRD2DRD4MEN1 | |
| SCHEMBL7503050 | 0.79 | DRD3 (0.60) | FYNDRD3DRD2DRD4MEN1 | |
| Bromide SCHEMBL10975000 | 0.78 | DRD2 (0.64) | FYNDRD3DRD2DRD4MEN1 | |
| SCHEMBL8128394 | 0.76 | FYN (0.63) | FYNDRD3DRD2DRD4MEN1 | |
| SCHEMBL7330393 | 0.75 | DRD2 (0.64) | DRD3DRD2DRD4HTR1AADRB2 | |
| SCHEMBL9759545 | 0.75 | HTR1A (0.64) | DRD3DRD2HTR1ACYP2D6LMNA | |
| SCHEMBL8699267 | 0.75 | CA1 (0.38) | MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |