Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HLA-A | P04439 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121302 | 0.91 | HRH1 (0.47) | SSTR5KCNH2HRH1CHRM2CHRM1 | |
| SCHEMBL9699544 | 0.89 | HRH1 (0.47) | SSTR5KCNH2HRH1CHRM2CHRM1 | |
| SCHEMBL9306027 | 0.88 | SSTR5 (0.38) | SSTR5KCNH2HRH1CHRM2CHRM1 | |
| Water SCHEMBL6662104 | 0.86 | KCNH2 (0.42) | SSTR5KCNH2HRH1CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL5124598 | 0.85 | KCNH2 (0.41) | SSTR5KCNH2HRH1CHRM2CHRM1 | |
| SCHEMBL9630368 | 0.84 | HRH1 (0.43) | SSTR5KCNH2HRH1CHRM2CHRM1 | |
| SCHEMBL4987952 | 0.83 | SSTR5 (0.38) | SSTR5KCNH2HRH1CHRM2CHRM1 | |
| SCHEMBL5114336 | 0.83 | HTR5A (0.41) | SSTR5KCNH2HRH1CHRM2CHRM1 | |
| SCHEMBL27299125 | 0.83 | CHRM2 (0.40) | CHRM2CHRM1CHRM3LMNATP53 | |
| SCHEMBL10507001 | 0.82 | SSTR5 (0.59) | SSTR5KCNH2HRH1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539420-B1 | SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2000-01-05 | — | — | EP | disclosed |
| US-5360807-A | Substituted thiazolyl and substituted pyridinyl derivatives | JANSSEN PHARMACEUTICA N.V. (BF) | 1994-11-01 | — | — | US | disclosed |
| EP-0539420-A1 | NOVEL SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001697-A1 | NOVEL SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-06 | — | — | WO | disclosed |