Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HLA-A | P04439 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9698779 | 0.90 | HRH1 (0.45) | SSTR5KCNH2TP53HTR1ADRD2 | |
| SCHEMBL8133192 | 0.88 | SSTR5 (0.39) | SSTR5KCNH2TP53HTR1ADRD2 | |
| SCHEMBL8121302 | 0.88 | HRH1 (0.47) | SSTR5KCNH2TP53HTR1ADRD2 | |
| SCHEMBL9690941 | 0.85 | HRH1 (0.41) | SSTR5KCNH2TP53HTR1ADRD2 | |
| Fumaric Acid SCHEMBL10818165 | 0.83 | GPR6 (0.41) | SSTR5KCNH2TP53DRD4HRH1 | |
| SCHEMBL1152440 | 0.82 | HPGD (0.38) | SSTR5KCNH2TP53HTR1ADRD2 | |
| SCHEMBL10382570 | 0.81 | SLC6A9 (0.44) | SSTR5KCNH2TP53HTR1ADRD2 | |
| SCHEMBL27299125 | 0.81 | CHRM2 (0.40) | TP53CHRM2CHRM1CHRM3LMNA | |
| SCHEMBL9629371 | 0.80 | HTR1A (0.42) | SSTR5KCNH2TP53HTR1ADRD2 | |
| SCHEMBL8128050 | 0.79 | NOS2 (0.53) | MEN1LMNAGAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360807-A | Substituted thiazolyl and substituted pyridinyl derivatives | JANSSEN PHARMACEUTICA N.V. (BF) | 1994-11-01 | — | — | US | disclosed |
| EP-0539420-A1 | NOVEL SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001697-A1 | NOVEL SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-06 | — | — | WO | disclosed |