Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.55 |
| ▸ | DRD3 | P35462 | 8/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 5/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | GOT1 | P17174 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131064 | 0.81 | GOT1 (0.53) | DRD2DRD3DRD4ADRA1AGAA | |
| SCHEMBL5423525 | 0.80 | DRD2 (0.52) | DRD2DRD3DRD4ADRA1AGAA | |
| SCHEMBL5423523 | 0.80 | DRD2 (0.52) | DRD2DRD3DRD4ADRA1AGAA | |
| SCHEMBL14489544 | 0.80 | DRD2 (0.47) | DRD2DRD3DRD4ADRA1AGAA | |
| SCHEMBL976063 | 0.79 | ADRA1A (0.73) | DRD2DRD3ADRA1AHTR1A | |
| SCHEMBL7461517 | 0.79 | DRD2 (0.45) | DRD2DRD3DRD4ADRA1AGAA | |
| SCHEMBL7471431 | 0.79 | DRD2 (0.50) | DRD2DRD3DRD4ADRA1AGAA | |
| SCHEMBL7471426 | 0.79 | DRD2 (0.50) | DRD2DRD3DRD4ADRA1AGAA | |
| SCHEMBL7461524 | 0.79 | DRD2 (0.45) | DRD2DRD3DRD4ADRA1AGAA | |
| SCHEMBL6481719 | 0.78 | DRD2 (0.58) | DRD2DRD3DRD4ADRA1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763031-B1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 2000-05-10 | — | — | EP | disclosed |
| EP-0906100-A1 | USE OF 5-HT 1A? RECEPTOR ANTAGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1999-04-07 | — | — | EP | disclosed |
| US-5723464-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANXIETY OR DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-03 | — | — | US | disclosed |
| WO-1997031637-A1 | USE OF 5-HT1A RECEPTOR ANTAGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-09-04 | — | — | WO | disclosed |
| EP-0763031-A1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033743-A1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1995-12-14 | — | — | WO | disclosed |