Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | PPARA | Q07869 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | UTRN | P46939 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893515 | 0.86 | KDM4E (0.70) | KDM4ELMNAMAPTPPARGPPARA | |
| SCHEMBL2930640 | 0.85 | KDM4E (0.74) | KDM4ELMNAMAPTPPARGPPARA | |
| SCHEMBL6607518 | 0.83 | LMNA (0.60) | KDM4ELMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL821081 | 0.83 | KDM4E (0.57) | KDM4ELMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7906307 | 0.82 | KDM4E (0.56) | KDM4ELMNAMAPTALDH1A1PPARG | |
| SCHEMBL27656200 | 0.81 | KDM4E (0.57) | KDM4EMAPTALDH1A1PPARGPPARA | |
| SCHEMBL13958893 | 0.81 | KDM4E (0.47) | KDM4ELMNAMAPTALDH1A1PPARG | |
| SCHEMBL6293021 | 0.81 | KDM4E (0.52) | KDM4ELMNAMAPTALDH1A1PPARG | |
| SCHEMBL6505735 | 0.81 | KDM4E (0.55) | KDM4ELMNAMAPTALDH1A1PPARG | |
| SCHEMBL10652783 | 0.81 | HSD17B10 (0.61) | KDM4ELMNAMAPTALDH1A1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1056372-C | Thiazolidinedione derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-09-13 | — | — | CN | disclosed |
| EP-0605228-B1 | Thiazolidinedione derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-03-01 | — | — | EP | disclosed |
| US-5489602-A | HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-06 | — | — | US | disclosed |
| CN-1094726-A | Thiazolidine diketone derivative, their preparation method and purposes | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-11-09 | — | — | CN | disclosed |
| EP-0605228-A1 | Thiazolidinedione derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1994-07-06 | — | — | EP | disclosed |