Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 4/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12949557 | 0.94 | COMT (0.39) | COMT | |
| SCHEMBL8128024 | 0.86 | COMT (0.38) | COMTGPR84MEN1NR1I2LMNA | |
| SCHEMBL8128383 | 0.86 | SMPD1 (0.36) | SMPD1GPR84MEN1NR1I2LMNA | |
| Bromide SCHEMBL9290788 | 0.84 | SMPD1 (0.36) | SMPD1GPR84MEN1NR1I2LMNA | |
| SCHEMBL8128852 | 0.82 | S1PR2 (0.40) | SMPD1 | |
| SCHEMBL9915359 | 0.81 | COMT (0.40) | COMTMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL8130321 | 0.80 | ALDH1A1 (0.38) | SMPD1PLA2G2AALDH1A1HPGD | |
| SCHEMBL8136252 | 0.80 | COMT (0.56) | COMTMEN1NR1I2LMNACHRM2 | |
| SCHEMBL8119394 | 0.80 | THRA (0.41) | — | |
| SCHEMBL12949563 | 0.79 | CYP1A2 (0.33) | LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0427765-B1 | ALKOXY-4(1H)-PYRIDONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USE AS DRUGS | GOEDECKE AG (DE) | 2000-01-05 | — | — | EP | disclosed |
| US-5322844-A | Cardiovascular disorders, antiinflammatory agents, antiallergens | GODECKE AKTIENGESELLSCHAFT (DE) | 1994-06-21 | — | — | US | disclosed |
| US-5185352-A | Treating or preventing cardiovascular disorders | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1993-02-09 | — | — | US | disclosed |
| EP-0427765-A1 | ALKOXY-4(1H)-PYRIDONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USE AS DRUGS | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-05-22 | — | — | EP | disclosed |
| WO-1990001477-A1 | ALKOXY-4(1H)-PYRIDONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USE AS DRUGS | Gödecke Aktiengesellschaft (DE) | 1990-02-22 | — | — | WO | disclosed |
| EP-0354495-A1 | Alkoxy-4(1H)-pyridone derivatives, process for their preparation and their pharmaceutical use | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-02-14 | — | — | EP | disclosed |