Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 4/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12949557 | 0.86 | COMT (0.39) | COMTTYRPDE4BGAATP53 | |
| SCHEMBL9915355 | 0.84 | COMT (0.38) | COMTPDE4BGAAPGAM1CA9 | |
| SCHEMBL8134142 | 0.81 | SMPD1 (0.39) | COMTMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8128024 | 0.79 | COMT (0.38) | COMTTYRMEN1ALDH1A1MAPT | |
| SCHEMBL9291043 | 0.77 | COMT (0.45) | COMT | |
| SCHEMBL8136252 | 0.76 | COMT (0.56) | COMTMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6900184 | 0.75 | COMT (0.63) | COMT | |
| SCHEMBL12949563 | 0.74 | CYP1A2 (0.33) | GAAALDH1A1MAPTCYP1A2CYP2C9 | |
| SCHEMBL8134390 | 0.73 | NPC1 (0.41) | GAAMEN1NPC1RAB9AKMT2A | |
| SCHEMBL8130166 | 0.73 | COMT (0.44) | COMTTYRMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | COMT 1386/4885TYR 4830/4885PDE4B 1780/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | COMT 1386/4885TYR 4830/4885PDE4B 1780/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | COMT 1386/4885TYR 4830/4885PDE4B 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.