Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753159 | 0.87 | KDM4E (0.62) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL6166997 | 0.85 | SLC2A1 (0.54) | SLC2A1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL2724207 | 0.85 | MAPT (0.47) | SLC2A1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL1528952 | 0.85 | ALDH1A1 (0.47) | SLC2A1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL28255681 | 0.84 | SLC2A1 (0.63) | SLC2A1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL6866579 | 0.83 | RARB (0.51) | ALDH1A1KDM4EHSD17B10GAATDP1 | |
| SCHEMBL12002526 | 0.82 | SLC2A1 (0.54) | SLC2A1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL10260635 | 0.81 | SLC2A1 (0.51) | SLC2A1ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL28081743 | 0.81 | MAPT (0.51) | SLC2A1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL16937873 | 0.81 | TDP1 (0.57) | SLC2A1ALDH1A1KDM4EHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100272-A | Tetracyclic spiro compounds as 5HT1B receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-08-08 | — | — | US | disclosed |
| EP-0888358-A1 | PIPERIDINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034901-A1 | PIPERIDINE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-09-25 | — | — | WO | disclosed |