Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129697 | 0.83 | MEN1 (0.47) | MEN1KMT2AKDM4EMAPTMAPK1 | |
| SCHEMBL10782883 | 0.72 | CES2 (0.55) | MAPK1LMNARAB9A | |
| SCHEMBL17431865 | 0.71 | MAPT (0.44) | MEN1KMT2AKDM4EMAPTADRA2B | |
| SCHEMBL8275459 | 0.70 | MAPT (0.46) | MEN1KMT2AKDM4EMAPTADRA2B | |
| SCHEMBL8120918 | 0.69 | KDM4E (0.49) | MEN1KMT2AKDM4EMAPTADRA2B | |
| SCHEMBL18879718 | 0.69 | MAPT (0.40) | MEN1KMT2AKDM4EMAPTADRA2B | |
| SCHEMBL13757013 | 0.69 | MAPT (0.45) | MEN1KMT2AKDM4EMAPTNPC1 | |
| SCHEMBL14924079 | 0.68 | MAPT (0.42) | KMT2AKDM4EMAPTADRA2BMAPK1 | |
| SCHEMBL24681374 | 0.68 | SMN1; SMN2 (0.45) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL28502420 | 0.68 | MAPT (0.51) | MEN1KMT2AKDM4EMAPTADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675880-B1 | QUINOLINE DISULFIDES AS INTERMEDIATES | ARCHIMICA SPA (IT) | 2000-01-05 | — | — | EP | claimed |
| EP-0675880-B1 | QUINOLINE DISULFIDES AS INTERMEDIATES | ARCHIMICA SPA (IT) | 2000-01-05 | — | — | EP | disclosed |
| US-5731433-A | Process for the preparation of rufloxacin and salts thereof | ARCHIMICA SPA (IT) | 1998-03-24 | — | — | US | disclosed |
| EP-0725785-B1 | PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS THEREOF | ARCHIMICA SPA (IT) | 1997-07-23 | — | — | EP | disclosed |
| EP-0725785-A1 | PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS THEREOF | ARCHIMICA SPA (IT) | 1996-08-14 | — | — | EP | disclosed |
| EP-0675880-A1 | QUINILONE DISULFIDE AS INTERMEDIATES | ARCHIMICA S.P.A. (IT) | 1995-10-11 | — | — | EP | disclosed |
| WO-1995011907-A1 | PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS THEREOF | ARCHIMICA S.P.A. (IT) | 1995-05-04 | — | — | WO | disclosed |
| WO-1995011886-A1 | QUINILONE DISULFIDE AS INTERMEDIATES | ARCHIMICA S.P.A. (IT) | 1995-05-04 | — | — | WO | disclosed |