Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.46 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4563153 | 0.82 | OPRM1 (0.56) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL8136258 | 0.82 | HTR1A (0.70) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL27347000 | 0.79 | HTR1A (0.73) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL27351354 | 0.79 | HTR1A (0.73) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL8010247 | 0.79 | HTR1A (1.00) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL7474356 | 0.79 | HTR1A (1.00) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL7474354 | 0.79 | HTR1A (1.00) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL8548576 | 0.70 | HTR1A (0.57) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL8548570 | 0.70 | HTR1A (0.57) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL8546364 | 0.68 | HTR1A (0.53) | HTR1AMEN1KMT2AADRA1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763031-B1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 2000-05-10 | — | — | EP | claimed |
| EP-0763031-B1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 2000-05-10 | — | — | EP | disclosed |
| US-5723464-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANXIETY OR DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-03 | — | — | US | disclosed |