Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL813627

CCCC1Sc2ccccc2N1[Si](OCC)(OCC)OCC.S.S.S.S

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ PPARG P37231 1/20 0.38
▸ BCHE P06276 1/20 0.33
▸ GSK3B P49841 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.30
▸ POLB P06746 1/20 0.30
▸ PKM P14618 1/20 0.30
▸ TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8525463 0.99 PPARG (0.39) PPARGBCHEGSK3BALDH1A1POLB
Hydrogen Sulfide SCHEMBL7021865 0.87 PPARG (0.39) PPARGBCHEGSK3BALDH1A1POLB
SCHEMBL28159336 0.64 BCHE (0.37) BCHEALDH1A1POLB
SCHEMBL28916911 0.64 BCHE (0.37) PPARGBCHEALDH1A1POLBTSHR
Bromide SCHEMBL10628545 0.63 PPARG (0.47) PPARGBCHEGSK3BALDH1A1POLB
SCHEMBL11515966 0.62 MAOA (0.41) PPARGBCHEALDH1A1POLBPKM
SCHEMBL8008940 0.61 PPARG (0.43) PPARGBCHEGSK3BALDH1A1POLB
SCHEMBL27807688 0.60 GSK3B (0.37) PPARGBCHEGSK3BALDH1A1POLB
SCHEMBL7992802 0.60 MAOA (0.42) PPARGALDH1A1POLBPKMTSHR
SCHEMBL27926326 0.59 BCHE (0.38) BCHEGSK3BALDH1A1POLBTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10179850-B2 Foamable composition, process for producing the same and foam ASAHI KASEI CHEMICALS CORPORATION (JP) 2019-01-15 — — US disclosed
EP-2546291-B1 FOAM COMPOSITION, METHOD FOR PRODUCING SAME, AND FOAM ASAHI KASEI CHEMICALS CORP (JP) 2016-04-20 — — EP disclosed
EP-2189464-B1 Terminating compounds, polymers, and their uses in rubber compositions and tires GOODYEAR TIRE & RUBBER (US) 2013-11-06 — — EP disclosed
EP-2546291-A1 FOAM COMPOSITION, METHOD FOR PRODUCING SAME, AND FOAM Asahi Kasei Chemicals Corporation (JP) 2013-01-16 — — EP disclosed
EP-2154192-B1 PLY FORMED USING SPECIFIED RUBBER COMPOSITION, AND PNEUMATIC TIRE UTILIZING THEM SUMITOMO RUBBER IND (JP) 2013-01-02 — — EP disclosed
US-20120322905-A1 Foamable Composition, Process for Producing the Same and Foam ASAHI KASEI CHEMICALS CORPORATION (JP) 2012-12-20 — — US disclosed
US-8071689-B2 Methods of making siloxy-amine functionalized rubbery polymers and uses thereof in rubber compositions for tires THE GOODYEAR TIRE & RUBBER COMPANY (US) 2011-12-06 — — US disclosed
US-8053512-B2 Sulfide modified elastomeric polymers STYRON EUROPE GMBH (CH) 2011-11-08 — — US disclosed
US-8022159-B2 Terminating compounds, polymers, and their uses in rubber compositions and tires THE GOODYEAR TIRE & RUBBER COMPANY (US) 2011-09-20 — — US disclosed
US-7745523-B1 Coupling compounds and their uses in rubber compositions and tires THE GOODYEAR TIRE & RUBBER COMPANY (US) 2010-06-29 — — US disclosed
US-20100144950-A1 COUPLING COMPOUNDS AND THEIR USES IN RUBBER COMPOSITIONS AND TIRES THE GOODYEAR TIRE & RUBBER COMPANY (US) 2010-06-10 — — US disclosed
US-20100132863-A1 PLY, CLINCH AND TREAD FORMED BY USING A SPECIFIC RUBBER COMPOSITION AND PNEUMATIC TIRE USING THE SAME SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2010-06-03 — — US disclosed
US-20100130664-A1 TERMINATING COMPOUNDS, POLYMERS, AND THEIR USES IN RUBBER COMPOSITIONS AND TIRES THE GOODYEAR TIRE & RUBBER COMPANY (US) 2010-05-27 — — US disclosed
EP-2189464-A1 Terminating compounds, polymers, and their uses in rubber compositions and tires THE GOODYEAR TIRE & RUBBER COMPANY (US) 2010-05-26 — — EP disclosed
US-20100069568-A1 SULFIDE MODIFIED ELASTOMERIC POLYMERS DOW GLOBAL TECHNOLOGIES INC. (US) 2010-03-18 — — US disclosed
US-20100063202-A1 Methods of Making Siloxy-Amine Functionalized Rubbery Polymers and Uses Thereof in Rubber Compositions for Tires THE GOODYEAR TIRE & RUBBER COMPANY (US) 2010-03-11 — — US disclosed
EP-2154192-A1 PLY, CLINCH AND TREAD FORMED USING SPECIFIED RUBBER COMPOSITION, AND PNEUMATIC TIRE UTILIZING THEM Sumitomo Rubber Industries, Ltd. (JP) 2010-02-17 — — EP disclosed
EP-2121350-A1 SULFIDE MODIFIED ELASTOMERIC POLYMERS Dow Global Technologies Inc. (US) 2009-11-25 — — EP disclosed
US-20090203826-A1 METHODS OF MAKING SILOXY-IMINE FUNCTIONALIZED RUBBERY POLYMERS AND USES THEREOF IN RUBBER COMPOSITIONS FOR TIRES RACHITA MICHAEL JOSEPH 2009-08-13 — — US disclosed
WO-2008076875-A1 SULFIDE MODIFIED ELASTOMERIC POLYMERS DOW GLOBAL TECHNOLOGIES INC. (US) 2008-06-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100144950-A1 COUPLING COMPOUNDS AND THEIR USES IN RUBBER COMPOSITIONS AND TIRES RIF1, TERB1, RAD51 PPARG 3748/4885BCHE 3413/4885GSK3B 4464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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