Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849718 | 0.75 | ADRA1B (0.45) | ADRA1BADRA1A | |
| SCHEMBL7852402 | 0.72 | ADRA1B (0.66) | ADRA1BADRA1A | |
| SCHEMBL8127872 | 0.72 | ADRA1B (0.66) | ADRA1BADRA1A | |
| SCHEMBL8138172 | 0.71 | CHRNB2 (0.37) | ADRA2AADRA2BADRA2CDRD2HTR2A | |
| Hydrochloric Acid SCHEMBL8139207 | 0.71 | ADRA1B (0.65) | ADRA1BADRA1A | |
| Hydrochloric Acid SCHEMBL8139060 | 0.71 | ADRA1B (0.65) | ADRA1BADRA1A | |
| SCHEMBL8142221 | 0.70 | ADRA1B (0.53) | ADRA1BADRA1A | |
| SCHEMBL9263586 | 0.69 | DRD2 (0.41) | ADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL9261796 | 0.69 | DRD2 (0.41) | ADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL9261794 | 0.69 | DRD2 (0.41) | ADRA2AADRA2BADRA2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5597823-A | TREATING BENIGN PROSTATIC HYPERPLASIA | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| WO-1996022992-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |