Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007673 | 0.81 | AKR1B1 (0.57) | ALDH1A1LMNASMN1; SMN2POLBAKR1B1 | |
| SCHEMBL8141751 | 0.74 | ALDH1A1 (0.34) | ALDH1A1LMNASMN1; SMN2POLBAKR1B1 | |
| SCHEMBL8141754 | 0.74 | ALDH1A1 (0.34) | ALDH1A1LMNASMN1; SMN2POLBAKR1B1 | |
| SCHEMBL8137792 | 0.69 | TBXA2R (0.44) | ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL8881014 | 0.69 | TBXA2R (0.44) | ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL11663201 | 0.67 | AKR1B1 (0.61) | ALDH1A1SMN1; SMN2AKR1B1PDK2MAPT | |
| SCHEMBL4918684 | 0.67 | SRD5A2 (0.66) | ALDH1A1LMNASMN1; SMN2PDK2ADRA2A | |
| SCHEMBL11567084 | 0.67 | AKR1B1 (0.54) | ALDH1A1SMN1; SMN2AKR1B1KDM4EMAPT | |
| SCHEMBL9046208 | 0.66 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2POLBKDM4E | |
| SCHEMBL26118036 | 0.66 | TSHR (0.57) | ALDH1A1LMNASMN1; SMN2PDK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549352-B1 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO KK (JP) | 2000-03-01 | — | — | EP | disclosed |
| US-5607955-A | TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| US-5478840-A | Imidazo(4,5-b)pyridine derivatives used as antagonism to angiotensin ii receptors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5378701-A | Angiotensin II inhibitors; hypotensive agents; congestive heart and kidney failure; glaucoma | KYOWA HAKKO KOGYO (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0549352-A2 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |