Sugi Predict

Sugi Predict / Compounds / SCHEMBL4918684

SCHEMBL4918684

SCHEMBL4918684

COC(=O)c1ccc2c(c1)Cc1ccccc1-2

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SRD5A2 P31213 2/20 0.66
▸ MAPT P10636 3/20 0.58
▸ KDM4E B2RXH2 3/20 0.58
▸ ALDH1A1 P00352 2/20 0.58
▸ HPGD P15428 1/20 0.58
▸ TRPA1 O75762 3/20 0.57
▸ HTR2C P28335 2/20 0.56
▸ HTR2B P41595 2/20 0.56
▸ DRD2 P14416 1/20 0.56
▸ ADRA1D P25100 1/20 0.56
▸ HTR2A P28223 1/20 0.56
▸ HTR7 P34969 1/20 0.56
▸ ADRA1A P35348 1/20 0.56
▸ ADRA1B P35368 1/20 0.56
▸ CYP1A2 P05177 1/20 0.55
▸ ADRA2A P08913 1/20 0.55
▸ MAOA P21397 1/20 0.55
▸ SLC6A2 P23975 1/20 0.55
▸ SLC6A4 P31645 1/20 0.55
▸ RAB9A P51151 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22524482 0.94 TRPA1 (0.57) SRD5A2MAPTKDM4EALDH1A1HPGD
SCHEMBL7042343 0.87 TRPA1 (0.51) SRD5A2MAPTKDM4EALDH1A1HPGD
Fluorene SCHEMBL27412062 0.85 TSHR (0.68) SRD5A2MAPTKDM4EALDH1A1HPGD
Fluorene SCHEMBL2708609 0.85 TSHR (0.68) SRD5A2MAPTKDM4EALDH1A1HPGD
SCHEMBL13550865 0.83 PTPRC (0.54) MAPTKDM4EALDH1A1HPGDTRPA1
SCHEMBL5727975 0.83 SRD5A2 (0.60) SRD5A2MAPTKDM4EALDH1A1HPGD
SCHEMBL6907035 0.83 CA1 (0.55) MAPTKDM4EALDH1A1HPGDTRPA1
SCHEMBL8920996 0.83 CA1 (0.55) MAPTKDM4EALDH1A1HPGDTRPA1
SCHEMBL23166496 0.83 MAPT (0.53) SRD5A2MAPTKDM4EALDH1A1HPGD
SCHEMBL2395323 0.83 MAPT (0.53) SRD5A2MAPTKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240269293-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF OD THERAPEUTICS LIMITED (CN) 2024-08-15 — — US disclosed
EP-4313154-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF OD Therapeutics Limited (HK) 2024-02-07 — — EP disclosed
CN-117355337-A Protein-macromolecule conjugates and methods of use thereof 奥迪曼药业科技有限公司 2024-01-05 — — CN disclosed
US-20220401561-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF AJ SCIENCES (YIXING) CO., LTD (CN) 2022-12-22 — — US disclosed
US-20220401561-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF AJ SCIENCES (YIXING) CO., LTD (CN) 2022-12-22 — — US disclosed
WO-2022212362-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) 2022-10-06 — — WO disclosed
EP-4037715-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF Beijing Xuanyi Pharmasciences Co., Ltd. (CN) 2022-08-10 — — EP disclosed
CN-114630818-A Protein-macromolecule conjugates and methods of use thereof 北京轩义医药科技有限公司 2022-06-14 — — CN disclosed
CN-113727961-A Dicarboxylic acids, process for producing the same, and use thereof 大阪燃气化学有限公司 2021-11-30 — — CN disclosed
WO-2021067458-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) 2021-04-08 — — WO disclosed
CN-101001900-B Process for producing aromatic compound polymer SUMITOMO CHEMICAL CO 2011-04-20 — — CN disclosed
CN-101914111-A The preparation method of aromatic compound polymer SUMITOMO CHEMICAL CO 2010-12-15 — — CN disclosed
US-20080200551-A1 Flourene Derivative ASTELLAS PHARMA INC. (JP) 2008-08-21 — — US disclosed
US-20080171788-A1 Medicament For Irritable Bowel Syndrome ASTELLAS PHARMA INC. (JP) 2008-07-17 — — US disclosed
US-20080161419-A1 Prophylactic Antimigraine Agents ASTELLAS PHARMA INC. (JP) 2008-07-03 — — US disclosed
EP-1852129-A1 REMEDY FOR IRRITABLE BOWEL SYNDROME Astellas Pharma Inc. (JP) 2007-11-07 — — EP disclosed
CN-101001900-A Process for producing aromatic compound polymer SUMITOMO CHEMICAL CO (JP) 2007-07-18 — — CN disclosed
EP-1728784-A1 FLUORENE DERIVATIVE Astellas Pharma Inc. (JP) 2006-12-06 — — EP disclosed
EP-1716867-A1 PREVENTIVES FOR MIGRAINE Astellas Pharma Inc. (JP) 2006-11-02 — — EP disclosed
CN-1842517-A Fluorene derivatives ASTELLAS PHARMA INC (JP) 2006-10-04 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240269293-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF CD44, MACROD1, MSN SRD5A2 4748/4885MAPT 1112/4885KDM4E 3612/4885
US-20080161419-A1 Prophylactic Antimigraine Agents HTR2B, HTR7, HTR1A SRD5A2 3866/4885MAPT 3582/4885KDM4E 3252/4885
US-20080200551-A1 Flourene Derivative HTR2B, HTR7, HTR2C SRD5A2 4493/4885MAPT 3927/4885KDM4E 3405/4885
US-20080171788-A1 Medicament For Irritable Bowel Syndrome HTR7, HTR5A, HTR3B SRD5A2 1526/4885MAPT 4073/4885KDM4E 3865/4885
US-20220401561-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF CD44, SSB, DNPEP SRD5A2 4699/4885MAPT 1431/4885KDM4E 3521/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.