Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139084 | 0.78 | DRD2 (0.44) | HSD17B10MAPTMEN1KMT2AHTT | |
| SCHEMBL8130875 | 0.78 | HTR3E (0.48) | CYP3A4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8128832 | 0.78 | ALDH1A1 (0.50) | HSD17B10CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL8148983 | 0.74 | PDK2 (0.41) | MAPK1MAPTKMT2ASMN1; SMN2HTT | |
| SCHEMBL569307 | 0.73 | LMNA (0.61) | HSD17B10CHRNA7CYP3A4ALOX15CHRNB2 | |
| SCHEMBL16924863 | 0.73 | LMNA (0.61) | HSD17B10CHRNA7CYP3A4ALOX15CHRNB2 | |
| SCHEMBL8142857 | 0.72 | ALDH1A1 (0.53) | HSD17B10RAB9AKMT2ANPC1COMT | |
| SCHEMBL8139399 | 0.71 | ALDH1A1 (0.44) | HSD17B10ALOX15MAPK1MAPTRAB9A | |
| SCHEMBL576673 | 0.71 | LMNA (0.58) | HSD17B10CHRNA7CYP3A4ALOX15CHRNB2 | |
| SCHEMBL577708 | 0.71 | LMNA (0.58) | HSD17B10CHRNA7CYP3A4ALOX15CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | claimed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | claimed |