Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL244112 | 0.84 | EGLN1 (0.68) | KDM4EEGLN1ALDH1A1 | |
| SCHEMBL3502575 | 0.84 | KDM4E (0.56) | KDM4EEGLN1ALDH1A1LMNASLC40A1 | |
| SCHEMBL12020192 | 0.83 | KDM4E (0.55) | KDM4EEGLN1ALDH1A1SLC40A1MAP2K1 | |
| SCHEMBL25985620 | 0.83 | KDM4E (0.55) | KDM4EEGLN1ALDH1A1SLC40A1MAP2K1 | |
| SCHEMBL11973430 | 0.82 | LMNA (0.56) | KDM4EEGLN1ALDH1A1LMNAPARP1 | |
| SCHEMBL344528 | 0.82 | ALDH1A1 (0.65) | KDM4EEGLN1ALDH1A1LMNASLC40A1 | |
| SCHEMBL16383149 | 0.80 | ALDH1A1 (0.70) | KDM4EEGLN1ALDH1A1LMNAPARP1 | |
| SCHEMBL16131034 | 0.80 | SLC40A1 (0.53) | KDM4EEGLN1ALDH1A1LMNASLC40A1 | |
| SCHEMBL28484520 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1LMNAPARP1 | |
| SCHEMBL13515356 | 0.79 | KDM4E (0.47) | KDM4EEGLN1ALDH1A1SLC40A1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112079832-A | Medicine for treating hysteromyoma and preparation method thereof | 黑龙江中医药大学 | 2020-12-15 | — | — | CN | disclosed |
| WO-2017123482-A1 | DIHYDROPYRIDO QUINAZOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2017-07-20 | — | — | WO | disclosed |
| WO-2017123482-A1 | DIHYDROPYRIDO QUINAZOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2017-07-20 | — | — | WO | disclosed |
| US-7470794-B2 | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-0808318-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | Abbott Laboratories (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5597823-A | TREATING BENIGN PROSTATIC HYPERPLASIA | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| WO-1996022992-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |