Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 15/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7733863 | 0.93 | MPO (0.56) | MPOHTR2ATRPM8HTR1AKMT2A | |
| SCHEMBL8129433 | 0.90 | HTR2A (0.55) | MPOHTR2ATRPM8HTR1AKMT2A | |
| SCHEMBL1304576 | 0.87 | MPO (0.60) | MPOHTR2ATRPM8HTR1AKMT2A | |
| SCHEMBL9093555 | 0.85 | HTR2A (0.55) | HTR2ATRPM8HTR1AGPR84SLC6A4 | |
| SCHEMBL7902192 | 0.81 | HTR2A (0.50) | MPOHTR2AHTR1AKMT2AGPR84 | |
| SCHEMBL25884870 | 0.79 | MPO (0.65) | MPOHTR2ATRPM8HTR1AKMT2A | |
| SCHEMBL22152521 | 0.78 | SLC6A4 (0.56) | HTR2ATRPM8HTR1AGPR84SLC6A4 | |
| SCHEMBL2122451 | 0.74 | MPO (0.75) | MPOHTR2ATRPM8HTR1AKMT2A | |
| SCHEMBL30969154 | 0.74 | MPO (0.75) | MPOHTR2ATRPM8HTR1AKMT2A | |
| SCHEMBL17979949 | 0.74 | NR3C1 (0.34) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971926-A1 | DIHYDROPYRAZINO 1,2-$i(A)-]INDOLE-1-ONE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI-SYNTHELABO (FR) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042710-A1 | DIHYDROPYRAZINO [1,2-A-]INDOLE-1-ONE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI-SYNTHELABO (FR) | 1998-10-01 | — | — | WO | disclosed |