Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 17/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8140362 | 0.93 | MPO (0.55) | MPOSLC6A4HTR2ATRPM8HTR1A | |
| SCHEMBL22152521 | 0.85 | SLC6A4 (0.56) | SLC6A4HTR2ATRPM8HTR1A | |
| SCHEMBL8129433 | 0.82 | HTR2A (0.55) | MPOSLC6A4HTR2ATRPM8HTR1A | |
| SCHEMBL5946187 | 0.82 | SLC6A4 (0.52) | MPOSLC6A4HTR2AHTR1AKMT2A | |
| SCHEMBL1304576 | 0.79 | MPO (0.60) | MPOSLC6A4HTR2ATRPM8HTR1A | |
| SCHEMBL14499878 | 0.79 | MPO (0.60) | MPOSLC6A4HTR2ATRPM8 | |
| SCHEMBL9093555 | 0.78 | HTR2A (0.55) | SLC6A4HTR2ATRPM8HTR1A | |
| SCHEMBL28604379 | 0.76 | HTR1A (0.34) | MPOSLC6A4HTR2ATRPM8HTR1A | |
| SCHEMBL27561383 | 0.76 | MPO (0.79) | MPOSLC6A4HTR2ATRPM8 | |
| SCHEMBL30817963 | 0.76 | DUT (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828325-B2 | A benzoxazolopiperazine derivative useful for treating Parkinson's diseases, schizophrenia, anxiety and depression | SOLVAY PHARMACEUTICALS B.V. (CH) | 2004-12-07 | — | — | US | disclosed |