Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | GLA | P06280 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218005 | 0.80 | KDM4E (0.60) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL4343748 | 0.80 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL2748825 | 0.80 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL8886947 | 0.78 | KDM4E (0.55) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL8242765 | 0.78 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL8138212 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL24853492 | 0.77 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDGAAMAPT | |
| Isonicotinonitrile SCHEMBL14975424 | 0.76 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL6809479 | 0.74 | POLB (0.42) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL1101766 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1HPGDGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5597823-A | TREATING BENIGN PROSTATIC HYPERPLASIA | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |