Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.46 |
| ▸ | PPARD | Q03181 | 6/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 15/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8137807 | 0.86 | CYP1A2 (0.43) | AKR1B1 | |
| SCHEMBL8139674 | 0.86 | L3MBTL1 (0.39) | FFAR1AKR1B1 | |
| SCHEMBL10443939 | 0.79 | LMNA (0.43) | — | |
| SCHEMBL10444127 | 0.79 | LMNA (0.43) | — | |
| SCHEMBL28279575 | 0.79 | PPARG (0.52) | PPARGPPARDFFAR1PPARA | |
| SCHEMBL6035025 | 0.78 | HSP90AA1 (0.44) | AKR1B1 | |
| SCHEMBL10443920 | 0.77 | PPARG (0.50) | PPARGPPARDFFAR1PPARA | |
| SCHEMBL7432114 | 0.77 | HTR1A (0.56) | PPARGPPARDFFAR1PPARA | |
| SCHEMBL6214519 | 0.77 | FFAR1 (0.59) | PPARGPPARDFFAR1PPARA | |
| SCHEMBL27347334 | 0.77 | FFAR1 (0.60) | PPARGPPARDFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019412-A1 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT 1D? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-07-19 | — | — | EP | disclosed |
| WO-1997007120-A9 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR ANTAGONISTS | — | 1997-04-03 | — | — | WO | disclosed |
| WO-1997007120-A1 | BIPHENYL(THIO)AMIDE AND BIPHENYLETHAN(THI)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-27 | — | — | WO | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |