Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.41 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.41 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.41 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8201947 | 0.82 | ALDH1A1 (0.45) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7351746 | 0.81 | SERPINE1 (0.55) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8190016 | 0.77 | MAPT (0.41) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8129450 | 0.77 | GRIA1 (0.47) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8139111 | 0.77 | MAPT (0.47) | MAPTHCAR3MEN1ALDH1A1CYP1A2 | |
| SCHEMBL8203096 | 0.71 | AKR1B1 (0.39) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3495950 | 0.70 | SERPINE1 (0.49) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7136419 | 0.70 | GRIK1 (0.53) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3496197 | 0.70 | GRIK1 (0.53) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL1926341 | 0.69 | ALDH1A1 (0.55) | GRIK1GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556393-B1 | FUSED PYRAZINE DERIVATIVE | YAMANOUCHI PHARMA CO LTD (JP) | 2000-07-26 | — | — | EP | disclosed |
| US-5283244-A | Anticonvulsants, nervous system disorders | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-02-01 | — | — | US | disclosed |
| EP-0556393-A1 | FUSED PYRAZINE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |