SCHEMBL8203096

SCHEMBL8203096

O=[N+]([O-])c1cc(C(F)(F)F)c(-n2ccnc2)cc1Nc1cccc(CO)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.39
AKR1C4 P17516 1/20 0.39
AKR1C3 P42330 1/20 0.39
AKR1C2 P52895 1/20 0.39
AKR1C1 Q04828 1/20 0.39
CYP1A2 P05177 2/20 0.38
MAPT P10636 2/20 0.38
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
MAPK1 P28482 1/20 0.38
CYP2C19 P33261 1/20 0.38
PMP22 Q01453 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
SERPINE1 P05121 1/20 0.38
EGFR P00533 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8199955 0.79 AKR1B1 (0.46) AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1
SCHEMBL8201947 0.76 ALDH1A1 (0.45) CYP1A2MAPTMEN1ALDH1A1LMNA
SCHEMBL7351746 0.75 SERPINE1 (0.55) CYP1A2MAPTMEN1ALDH1A1LMNA
SCHEMBL3495950 0.74 SERPINE1 (0.49) CYP1A2MAPTMEN1ALDH1A1LMNA
SCHEMBL8190016 0.72 MAPT (0.41) CYP1A2MAPTMEN1ALDH1A1LMNA
SCHEMBL8144201 0.71 GRIK1 (0.41) CYP1A2MAPTMEN1ALDH1A1LMNA
SCHEMBL8129450 0.69 GRIA1 (0.47) CYP1A2MAPTMEN1ALDH1A1LMNA
SCHEMBL8139064 0.69 ALDH1A1 (0.44) CYP1A2MAPTMEN1ALDH1A1LMNA
SCHEMBL1626270 0.68 EPAS1 (0.39) AKR1B1AKR1C4AKR1C3AKR1C2AKR1C1
SCHEMBL7136419 0.67 GRIK1 (0.53) CYP1A2MAPTMEN1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6121264-A GLUTAMATE RECEPTOR ANTAGONIST, AMPA RECEPTOR ANTAGONIST, NMDA-GLYCINE RECEPTOR ANTAGONIST, KAINIC ACID NEUROTOXICITY INHIBITOR, ANTIISCHEMIC AGENT, PSYCHOTROPIC AGENT YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 2000-09-19 US disclosed
EP-0919554-A1 IMIDAZOLE-SUBSTITUTED QUINOXALINEDIONE DERIVATIVES YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1999-06-02 EP disclosed