Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.36 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.36 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.36 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8194623 | 0.87 | MAPT (0.43) | MAPTGRIK1GRIA1GRIA2GRIA3 | |
| SCHEMBL8190346 | 0.83 | LMNA (0.45) | MAPTALDH1A1GRIK1GRIA1GRIA2 | |
| SCHEMBL8781503 | 0.81 | LMNA (0.41) | MAPTALDH1A1GRIK1GRIA1GRIA2 | |
| SCHEMBL7351746 | 0.80 | SERPINE1 (0.55) | MAPTSERPINE1ALDH1A1GRIK1GRIA1 | |
| SCHEMBL8201947 | 0.79 | ALDH1A1 (0.45) | MAPTSERPINE1ALDH1A1GRIK1GRIA1 | |
| SCHEMBL8194643 | 0.79 | MEN1 (0.42) | SERPINE1ALDH1A1MEN1KMT2APKM | |
| SCHEMBL8144201 | 0.77 | GRIK1 (0.41) | MAPTALDH1A1GRIK1GRIA1GRIA2 | |
| SCHEMBL8192774 | 0.76 | LMNA (0.49) | MAPTALDH1A1GRIK1GRIA1GRIA2 | |
| SCHEMBL8190261 | 0.76 | LMNA (0.51) | MAPTALDH1A1GRIK1GRIA1GRIA2 | |
| SCHEMBL8191460 | 0.74 | LMNA (0.49) | MAPTALDH1A1GRIK1GRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096743-A | 1,2,3,4-tetrahydroquinoxalinedione derivative | YAMANOUCHI PHARMACEUTICALS CO., LTD. (JP) | 2000-08-01 | — | — | US | disclosed |
| EP-0784054-A1 | 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-07-16 | — | — | EP | disclosed |