Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148004 | 0.82 | TDP1 (0.51) | TDP1MEN1KMT2APOLB | |
| SCHEMBL8138605 | 0.80 | NPC1 (0.48) | MEN1KMT2APOLBCACNA1I | |
| SCHEMBL8145102 | 0.79 | TDP1 (0.46) | TDP1MEN1KMT2APOLBHTT | |
| SCHEMBL8159848 | 0.79 | TDP1 (0.54) | TDP1MEN1KMT2APOLB | |
| SCHEMBL14586758 | 0.76 | HTR1A (0.46) | TDP1MEN1KMT2APOLBHTT | |
| SCHEMBL18850978 | 0.75 | TDP1 (0.50) | TDP1MEN1KMT2APOLBCYP2D6 | |
| SCHEMBL18850977 | 0.74 | HTR4 (0.41) | TDP1MEN1KMT2AHTR4POLB | |
| SCHEMBL29325547 | 0.74 | CARM1 (0.42) | TDP1KMT2APOLB | |
| SCHEMBL29325463 | 0.74 | POLB (0.41) | MEN1KMT2APOLBCHRM4 | |
| SCHEMBL19049361 | 0.74 | KDM4E (0.45) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |