Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 6/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 6/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153764 | 0.87 | CARM1 (0.39) | TDP1MEN1KMT2AHTTCARM1 | |
| SCHEMBL14586758 | 0.83 | HTR1A (0.46) | TDP1MEN1KMT2AHTTCARM1 | |
| SCHEMBL8159848 | 0.80 | TDP1 (0.54) | TDP1MEN1KMT2APOLBNPC1 | |
| SCHEMBL14586767 | 0.79 | CARM1 (0.47) | TDP1MEN1KMT2AHTTCARM1 | |
| SCHEMBL8145111 | 0.79 | TDP1 (0.45) | TDP1MEN1KMT2AHTTPOLB | |
| SCHEMBL8148004 | 0.77 | TDP1 (0.51) | TDP1MEN1KMT2APOLBNPC1 | |
| SCHEMBL26493872 | 0.77 | NPC1 (0.43) | KMT2ACARM1PRMT6HRH3TMEM97 | |
| SCHEMBL18850978 | 0.76 | TDP1 (0.50) | TDP1MEN1KMT2APOLBNPC1 | |
| SCHEMBL27369636 | 0.75 | MEN1 (0.36) | MEN1KMT2A | |
| SCHEMBL18850977 | 0.75 | HTR4 (0.41) | TDP1MEN1KMT2ACARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |