SCHEMBL8145654

SCHEMBL8145654

Nc1cccc(Oc2cc(Oc3cccc(N)c3C(F)(F)F)c(C(F)(F)F)c(C(F)(F)F)c2)c1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.36
MAPT P10636 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
GAA P10253 2/20 0.36
ALDH1A1 P00352 1/20 0.36
AR P10275 14/20 0.35
RCE1 Q9Y256 1/20 0.34
RAB9A P51151 1/20 0.33
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8144077 0.89 AR (0.36) L3MBTL1MAPTNPSR1GAAALDH1A1
SCHEMBL8144086 0.88 GAA (0.41) L3MBTL1MAPTNPSR1GAAALDH1A1
SCHEMBL8145675 0.85 L3MBTL1 (0.42) L3MBTL1MAPTNPSR1GAAALDH1A1
SCHEMBL8138103 0.85 MAPT (0.36) L3MBTL1MAPTNPSR1GAAALDH1A1
SCHEMBL8145754 0.84 CYP1A2 (0.35) L3MBTL1MAPTNPSR1GAAALDH1A1
SCHEMBL8145996 0.83 L3MBTL1 (0.38) L3MBTL1MAPTNPSR1GAAALDH1A1
SCHEMBL6317146 0.82 MAPT (0.41) L3MBTL1MAPTNPSR1GAAALDH1A1
SCHEMBL8152777 0.81 MAPT (0.51) L3MBTL1MAPTNPSR1GAAALDH1A1
SCHEMBL8138550 0.81 L3MBTL1 (0.42) L3MBTL1MAPTNPSR1GAAALDH1A1
SCHEMBL8152766 0.81 L3MBTL1 (0.36) L3MBTL1MAPTNPSR1ARRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed