SCHEMBL8145996

SCHEMBL8145996

Nc1cc(Oc2cccc(Oc3cc(N)c(C(F)(F)F)c(C(F)(F)F)c3)c2C(F)(F)F)cc(C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.38
MAPT P10636 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
AR P10275 14/20 0.37
GAA P10253 2/20 0.35
ALDH1A1 P00352 1/20 0.35
RAB9A P51151 1/20 0.35
RCE1 Q9Y256 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8146865 0.87 AR (0.38) L3MBTL1MAPTNPSR1ARGAA
SCHEMBL8147195 0.85 MAPT (0.43) L3MBTL1MAPTNPSR1ARGAA
SCHEMBL8152179 0.85 L3MBTL1 (0.35) L3MBTL1MAPTNPSR1ARALDH1A1
SCHEMBL8146599 0.84 L3MBTL1 (0.41) L3MBTL1MAPTNPSR1ARGAA
SCHEMBL8138460 0.84 AR (0.43) L3MBTL1MAPTNPSR1ARGAA
SCHEMBL8150901 0.83 L3MBTL1 (0.33) L3MBTL1MAPTNPSR1ARALDH1A1
SCHEMBL8145654 0.83 L3MBTL1 (0.36) L3MBTL1MAPTNPSR1ARGAA
SCHEMBL8139518 0.83 L3MBTL1 (0.35) L3MBTL1MAPTNPSR1ARALDH1A1
SCHEMBL8146207 0.83 AR (0.44) L3MBTL1MAPTARGAAALDH1A1
SCHEMBL8147716 0.83 L3MBTL1 (0.40) L3MBTL1MAPTNPSR1ARALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed