SCHEMBL8138103

SCHEMBL8138103

Nc1cccc(Oc2cc(F)c(C(F)(F)F)c(Oc3cccc(N)c3C(F)(F)F)c2)c1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.36
L3MBTL1 Q9Y468 3/20 0.36
NPSR1 Q6W5P4 1/20 0.36
GAA P10253 2/20 0.36
ALDH1A1 P00352 1/20 0.36
RCE1 Q9Y256 1/20 0.34
KDM4E B2RXH2 1/20 0.33
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
RAB9A P51151 1/20 0.33
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C19 P33261 1/20 0.32
PARP10 Q53GL7 1/20 0.31
LMNA P02545 1/20 0.31
ATM Q13315 1/20 0.31
ALOX5AP P20292 1/20 0.30
FEN1 P39748 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8146684 0.90 MAPT (0.36) MAPTL3MBTL1NPSR1GAAALDH1A1
SCHEMBL8145654 0.85 L3MBTL1 (0.36) MAPTL3MBTL1NPSR1GAAALDH1A1
SCHEMBL6317146 0.82 MAPT (0.41) MAPTL3MBTL1NPSR1GAAALDH1A1
SCHEMBL8143633 0.82 RAB9A (0.31) L3MBTL1RAB9A
SCHEMBL8152777 0.81 MAPT (0.51) MAPTL3MBTL1NPSR1GAAALDH1A1
SCHEMBL8138550 0.81 L3MBTL1 (0.42) MAPTL3MBTL1NPSR1GAAALDH1A1
SCHEMBL8146121 0.81 L3MBTL1 (0.33) MAPTL3MBTL1NPSR1RAB9ALMNA
SCHEMBL8138511 0.81 MAPT (0.39) MAPTL3MBTL1NPSR1GAAALDH1A1
SCHEMBL8152725 0.80 L3MBTL1 (0.48) MAPTL3MBTL1NPSR1GAAALDH1A1
SCHEMBL8143934 0.80 L3MBTL1 (0.33) MAPTL3MBTL1NPSR1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed