Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | POLB | P06746 | 3/20 | 0.77 |
| ▸ | TSHR | P16473 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6265055 | 0.87 | ALDH1A1 (1.00) | HPGDALDH1A1POLBTSHRSMN1; SMN2 | |
| SCHEMBL6271302 | 0.82 | POLB (0.66) | HPGDALDH1A1POLBNPC1RAB9A | |
| SCHEMBL6971489 | 0.81 | ALDH1A1 (0.69) | HPGDALDH1A1TSHRSMN1; SMN2LMNA | |
| SCHEMBL6272298 | 0.81 | TSHR (0.63) | HPGDALDH1A1POLBTSHRNPC1 | |
| SCHEMBL14409571 | 0.80 | TSHR (0.70) | HPGDALDH1A1POLBTSHRNPC1 | |
| SCHEMBL6331720 | 0.79 | ALDH1A1 (0.63) | HPGDALDH1A1POLBNPC1RAB9A | |
| SCHEMBL12911161 | 0.79 | TSHR (0.69) | TSHRNPC1RAB9AGLAKMT2A | |
| SCHEMBL19829315 | 0.79 | TSHR (0.69) | ALDH1A1POLBTSHRNPC1RAB9A | |
| SCHEMBL17541648 | 0.78 | OGA (0.60) | HPGDALDH1A1POLBTSHRNPC1 | |
| SCHEMBL12569718 | 0.78 | TSHR (0.68) | ALDH1A1POLBTSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166036-A | Lp(a)-lowering agent and apolipoprotein (a) formation suppressing agent | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0393607-B1 | Phenylcarboxylic acid derivatives having a hetero ring | OTSUKA PHARMA CO LTD (JP) | 1996-02-21 | — | — | EP | disclosed |
| US-5145865-A | Fatty acid, cholesterol synthesis inhibitors; enzyme inhibitors; antilipemic agents | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1992-09-08 | — | — | US | disclosed |
| EP-0393607-A2 | Phenylcarboxylic acid derivatives having a hetero ring | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-10-24 | — | — | EP | disclosed |