SCHEMBL8146121

SCHEMBL8146121

Nc1c(F)ccc(Oc2cc(F)c(C(F)(F)F)c(Oc3ccc(F)c(N)c3C(F)(F)F)c2)c1C(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.33
RAB9A P51151 1/20 0.33
EPAS1 Q99814 3/20 0.33
VEGFA P15692 1/20 0.33
MAPT P10636 2/20 0.31
LMNA P02545 1/20 0.31
ATM Q13315 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
AR P10275 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8145118 0.90 L3MBTL1 (0.35) L3MBTL1RAB9AEPAS1VEGFAMAPT
SCHEMBL8145319 0.83
SCHEMBL8152492 0.82 AR (0.42) L3MBTL1RAB9AEPAS1VEGFAAR
SCHEMBL8152832 0.82 GLA (0.33) L3MBTL1RAB9AEPAS1
SCHEMBL8139082 0.81 EPAS1 (0.36) L3MBTL1RAB9AEPAS1VEGFAAR
SCHEMBL8137137 0.81 ALDH1A1 (0.34) L3MBTL1RAB9AMAPT
SCHEMBL8138103 0.81 MAPT (0.36) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8151584 0.80
SCHEMBL8139009 0.80
SCHEMBL8150890 0.79

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed