Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.75 |
| ▸ | HPGD | P15428 | 11/20 | 0.75 |
| ▸ | MAPT | P10636 | 10/20 | 0.75 |
| ▸ | BLM | P54132 | 8/20 | 0.75 |
| ▸ | HTT | P42858 | 7/20 | 0.75 |
| ▸ | GAA | P10253 | 5/20 | 0.75 |
| ▸ | POLB | P06746 | 3/20 | 0.75 |
| ▸ | PLEC | Q15149 | 2/20 | 0.75 |
| ▸ | SAE1 | Q9UBE0 | 8/20 | 0.72 |
| ▸ | UBA2 | Q9UBT2 | 8/20 | 0.72 |
| ▸ | NSD2 | O96028 | 6/20 | 0.72 |
| ▸ | THRB | P10828 | 4/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.72 |
| ▸ | UBE2I | P63279 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.72 |
| ▸ | CASP1 | P29466 | 7/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8164257 | 0.91 | KDM4E (0.63) | KDM4EALDH1A1HPGDMAPTBLM | |
| SCHEMBL15032605 | 0.86 | SAE1 (0.76) | KDM4EALDH1A1HPGDMAPTBLM | |
| SCHEMBL15032610 | 0.84 | SAE1 (0.72) | KDM4EALDH1A1HPGDMAPTBLM | |
| SCHEMBL8163981 | 0.83 | KDM4E (0.73) | KDM4EALDH1A1HPGDMAPTBLM | |
| SCHEMBL8168066 | 0.81 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDMAPTBLM | |
| SCHEMBL8163982 | 0.80 | SAE1 (0.62) | KDM4EALDH1A1HPGDMAPTBLM | |
| SCHEMBL8161071 | 0.80 | SAE1 (0.75) | KDM4EALDH1A1HPGDMAPTBLM | |
| SCHEMBL8163952 | 0.79 | HPGD (0.58) | KDM4EALDH1A1HPGDMAPTBLM | |
| SCHEMBL4787894 | 0.78 | KDM4E (0.68) | KDM4EALDH1A1HPGDMAPTBLM | |
| SCHEMBL8163085 | 0.78 | KDM4E (0.66) | KDM4EALDH1A1HPGDMAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |