SCHEMBL8147121

SCHEMBL8147121

COC(=O)Cc1ccc(S)c(CC(=O)OC)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.53
GAA P10253 1/20 0.53
GFER P55789 1/20 0.53
CYP4F2 P78329 1/20 0.50
CYP4A11 Q02928 1/20 0.50
HSP90AB1 P08238 1/20 0.49
MAPT P10636 3/20 0.46
HPGD P15428 2/20 0.46
TSHR P16473 1/20 0.46
SMN1; SMN2 Q16637 6/20 0.44
NPC1 O15118 4/20 0.44
RAB9A P51151 4/20 0.44
SLC7A5 Q01650 1/20 0.43
LMNA P02545 1/20 0.42
PDK2 Q15119 1/20 0.42
PKM P14618 1/20 0.42
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
TP53 P04637 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8147867 0.86 ALDH1A1 (0.53) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL14301862 0.84 ALDH1A1 (0.57) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL377583 0.81 CYP4F2 (0.53) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL7906379 0.81 ALDH1A1 (0.51) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL8145260 0.81 ALDH1A1 (0.68) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL8151837 0.79 ALDH1A1 (0.66) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL2094025 0.79 GAA (0.53) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL2981821 0.78 ALDH1A1 (0.51) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL8146212 0.77 GAA (0.63) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL12062913 0.77 ALDH1A1 (0.54) ALDH1A1GAAGFERCYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6028090-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-02-22 US disclosed
US-5723480-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1998-03-03 US disclosed
US-5561148-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) 1996-10-01 US disclosed