SCHEMBL8145260

SCHEMBL8145260

COC(=O)Cc1ccc(O)c(CC(=O)OC)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.68
GAA P10253 4/20 0.68
GFER P55789 1/20 0.68
EGFR P00533 3/20 0.56
HSP90AB1 P08238 1/20 0.55
CYP4F2 P78329 1/20 0.51
CYP4A11 Q02928 1/20 0.51
TLR7 Q9NYK1 2/20 0.48
TSHR P16473 3/20 0.47
NFKB1 P19838 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
HPGD P15428 4/20 0.47
KDM4E B2RXH2 2/20 0.47
GLA P06280 1/20 0.47
MAPT P10636 3/20 0.47
YWHAG P61981 1/20 0.46
HIF1A Q16665 2/20 0.44
HSD17B10 Q99714 2/20 0.44
TP53 P04637 1/20 0.44
CYP1A2 P05177 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30523630 0.89 ALDH1A1 (0.59) ALDH1A1GAAGFEREGFRHSP90AB1
SCHEMBL7046438 0.89 ALDH1A1 (0.59) ALDH1A1GAAGFEREGFRHSP90AB1
SCHEMBL22273409 0.88 ALDH1A1 (0.67) ALDH1A1GAAGFEREGFRHSP90AB1
SCHEMBL4031952 0.87 ALDH1A1 (0.53) ALDH1A1GAAGFEREGFRHSP90AB1
SCHEMBL3586640 0.87 ALDH1A1 (0.60) ALDH1A1GAAGFEREGFRHSP90AB1
SCHEMBL8146212 0.86 GAA (0.63) ALDH1A1GAAGFEREGFRHSP90AB1
SCHEMBL7042014 0.85 GABRA1 (0.63) ALDH1A1GAAGFEREGFRHSP90AB1
SCHEMBL29446278 0.85 GAA (0.72) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL3668882 0.85 GAA (0.72) ALDH1A1GAAGFERHSP90AB1CYP4F2
SCHEMBL14301862 0.85 ALDH1A1 (0.57) ALDH1A1GAAGFEREGFRHSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6028090-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-02-22 US disclosed
US-5723480-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1998-03-03 US disclosed
US-5561148-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) 1996-10-01 US disclosed