SCHEMBL8145238

SCHEMBL8145238

Nc1cc(C(F)(F)F)cc(Oc2ccc(C(F)(F)F)c(Oc3cc(C(F)(F)F)cc(N)c3C(F)(F)F)c2)c1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.43
RAB9A P51151 1/20 0.43
MAPT P10636 3/20 0.41
LMNA P02545 1/20 0.41
ATM Q13315 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
AR P10275 10/20 0.34
HTR2A P28223 4/20 0.34
SLC6A4 P31645 4/20 0.34
KCNH2 Q12809 4/20 0.34
KDM4E B2RXH2 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8143447 0.91 L3MBTL1 (0.47) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8152693 0.88 L3MBTL1 (0.39) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8147336 0.86 L3MBTL1 (0.55) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8147453 0.86 L3MBTL1 (0.43) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8151871 0.86 AR (0.39) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8150893 0.83 L3MBTL1 (0.36) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8146241 0.82 MAPT (0.58) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8144086 0.81 GAA (0.41) L3MBTL1RAB9AMAPTNPSR1AR
SCHEMBL8139029 0.81 NR4A1 (0.40) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8147355 0.80 L3MBTL1 (0.38) L3MBTL1RAB9AMAPTLMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed