Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.57 |
| ▸ | FEN1 | P39748 | 2/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2071964 | 0.99 | ERCC5 (0.56) | ERCC5FEN1EPHX1PKMMMP1 | |
| SCHEMBL8930279 | 0.86 | MEN1 (0.60) | ERCC5FEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6890171 | 0.85 | MEN1 (0.62) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL1162696 | 0.81 | ERCC5 (0.63) | ERCC5FEN1EPHX1PKMMMP1 | |
| SCHEMBL22114353 | 0.81 | EPHX1 (0.64) | EPHX1ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL3867134 | 0.80 | MEN1 (0.59) | ERCC5FEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL22069676 | 0.78 | ALDH1A1 (0.62) | EPHX1ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL8738225 | 0.77 | PKM (0.74) | EPHX1PKMALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1728534 | 0.76 | ERCC5 (0.74) | ERCC5FEN1MMP1SMN1; SMN2MEN1 | |
| SCHEMBL28481853 | 0.75 | ERCC5 (0.59) | ERCC5FEN1EPHX1PKMMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-A1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998041525-A1 | PYRROLO[2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |