SCHEMBL8149794

SCHEMBL8149794

CON=C(c1nccs1)c1nccs1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
RBBP9 O75884 5/20 0.46
KMT2A Q03164 3/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
CYP1A2 P05177 3/20 0.40
CYP2D6 P10635 3/20 0.40
CYP2C19 P33261 3/20 0.40
CASP3 P42574 2/20 0.40
SENP8 Q96LD8 2/20 0.40
SENP7 Q9BQF6 2/20 0.40
SENP6 Q9GZR1 2/20 0.40
MAPT P10636 2/20 0.40
SMPD3 Q9NY59 1/20 0.35
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
FBP1 P09467 1/20 0.34
SNCA P37840 1/20 0.34
LMNA P02545 2/20 0.33
TSHR P16473 2/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL212884 0.82 RBBP9 (0.55) ALDH1A1RBBP9KMT2AL3MBTL1CYP1A2
SCHEMBL10785943 0.77 ALDH1A1 (0.46) ALDH1A1RBBP9KMT2AL3MBTL1CYP1A2
SCHEMBL8144573 0.71 RBBP9 (0.45) ALDH1A1RBBP9KMT2AL3MBTL1CYP1A2
SCHEMBL1009292 0.69
SCHEMBL28159401 0.69
SCHEMBL1254922 0.68 ALDH1A1 (0.59) ALDH1A1RBBP9KMT2AL3MBTL1CYP1A2
SCHEMBL213922 0.68 RBBP9 (0.52) ALDH1A1RBBP9KMT2AL3MBTL1CYP1A2
SCHEMBL13408363 0.68 ALDH1A1 (0.53) ALDH1A1RBBP9KMT2AL3MBTL1CYP1A2
Hydrochloric Acid SCHEMBL28652061 0.68 ALDH1A1 (0.59) ALDH1A1RBBP9KMT2AL3MBTL1CYP1A2
SCHEMBL8213363 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6020495-A Stereoselective method for synthesizing dolaphenine PHARM-ECO LABORATORIES, INC. (US) 2000-02-01 US disclosed
EP-0846107-A1 STEREOSELECTIVE METHOD FOR SYNTHESIZING DOLAPHENINE Pharmeco Laboratories, Inc. (US) 1998-06-10 EP disclosed
US-5750713-A Stereoselective method for synthesizing dolaphenine PHARM-ECO LABORATORIES, INC. (US) 1998-05-12 US disclosed
WO-1996039399-A1 STEREOSELECTIVE METHOD FOR SYNTHESIZING DOLAPHENINE PHARM-ECO LABORATORIES, INC. (US) 1996-12-12 WO disclosed