Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8372824 | 0.93 | MCHR1 (0.38) | MEN1KMT2AMAPK1MCHR1FEN1 | |
| Fumaric Acid SCHEMBL8146701 | 0.75 | KMT2A (0.43) | MEN1KMT2AMCHR1HTR2A | |
| SCHEMBL782565 | 0.74 | MCHR1 (0.49) | MEN1KMT2AMCHR1HTR2A | |
| SCHEMBL8154453 | 0.74 | MCHR1 (0.49) | MEN1KMT2AMCHR1HTR2A | |
| SCHEMBL8154457 | 0.74 | MCHR1 (0.49) | MEN1KMT2AMCHR1HTR2A | |
| Fumaric Acid SCHEMBL8373626 | 0.72 | HRH4 (0.40) | MCHR1HRH4HRH3HTR2A | |
| Fumaric Acid SCHEMBL8155294 | 0.72 | HRH4 (0.40) | MCHR1HRH4HRH3HTR2A | |
| SCHEMBL8147229 | 0.65 | MAPT (0.42) | MCHR1HRH3 | |
| SCHEMBL11838704 | 0.65 | CTSK (0.40) | KMT2AFEN1CTSK | |
| Fumaric Acid SCHEMBL8149381 | 0.62 | CASP1 (0.41) | MEN1KMT2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063803-A | ANALGESICS AND CHEMICAL INTERMEDIATES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-05-16 | — | — | US | disclosed |
| WO-1999065911-A1 | OCTAHYDROPYRROLO-[3,4-c]CARBAZOLES USEFUL AS ANALGESIC AGENTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-12-23 | — | — | WO | disclosed |