Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148345 | 0.90 | ALDH1A1 (0.48) | NPC1RAB9APOLBKDM4EDRD2 | |
| SCHEMBL8154275 | 0.80 | ALDH1A1 (0.50) | POLBKDM4EALDH1A1HTTHPGD | |
| SCHEMBL8150334 | 0.77 | ALDH1A1 (0.50) | NPC1RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL8516897 | 0.75 | KDM4E (0.33) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8150808 | 0.71 | TNKS (0.42) | RAB9APOLBKDM4EALDH1A1HTT | |
| SCHEMBL8604346 | 0.70 | ESR1 (0.39) | NPC1RAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL27015810 | 0.69 | KDM4E (0.72) | KDM4EDRD2DRD3ALDH1A1MAPK1 | |
| SCHEMBL14133855 | 0.65 | MAPT (0.58) | RAB9APOLBKDM4EALDH1A1HPGD | |
| SCHEMBL8909780 | 0.65 | KDM4E (0.48) | NPC1RAB9AKDM4EDRD2DRD3 | |
| SCHEMBL22045050 | 0.64 | TNKS (0.55) | RAB9AKDM4EALDH1A1HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999045926-A1 | CONDENSED HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AND IMMUNOMODULATORY AGENTS | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1999-09-16 | — | — | WO | claimed |
| US-5852204-A | Pyrrolo 3,2-b-!-carbazoles and 1H 1!benzothieno 2,3-f! indoles having anti-tumor activity | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1998-12-22 | — | — | US | claimed |
| EP-0741729-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995021170-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-10 | — | — | WO | claimed |
| US-6013807-A | Antitumor tetracyclic compounds | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2000-01-11 | — | — | US | disclosed |
| US-5852204-A | Pyrrolo 3,2-b-!-carbazoles and 1H 1!benzothieno 2,3-f! indoles having anti-tumor activity | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1998-12-22 | — | — | US | disclosed |
| US-5770598-A | ANTITUMOR AGENTS; REACTING WITH CARBONYL DIIMIDAZOLE AND AMIDOXIMES | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1998-06-23 | — | — | US | disclosed |
| EP-0741729-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995021170-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-10 | — | — | WO | disclosed |