Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 7/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 7/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.55 |
| ▸ | WEE1 | P30291 | 2/20 | 0.55 |
| ▸ | BTK | Q06187 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8143371 | 0.82 | FGFR1 (0.67) | SRCFGFR1RIPK2NOD2ACVR1 | |
| SCHEMBL7588184 | 0.75 | SRC (0.61) | SRCFGFR1RIPK2NOD2ACVR1 | |
| SCHEMBL8142094 | 0.73 | FGFR1 (0.55) | SRCFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL6640079 | 0.72 | SRC (0.83) | SRCFGFR1RIPK2NOD2ACVR1 | |
| Pd-0166285 SCHEMBL30250248 | 0.71 | FGFR1 (1.00) | SRCFGFR1RIPK2NOD2ACVR1 | |
| SCHEMBL6642349 | 0.71 | SRC (1.00) | SRCFGFR1RIPK2NOD2ACVR1 | |
| Pd-0166285 SCHEMBL133914 | 0.71 | FGFR1 (1.00) | SRCFGFR1RIPK2NOD2ACVR1 | |
| Pd-0166285 SCHEMBL15106017 | 0.70 | FGFR1 (0.98) | SRCFGFR1RIPK2NOD2ACVR1 | |
| Pd-0166285 SCHEMBL30276696 | 0.70 | FGFR1 (0.98) | SRCFGFR1RIPK2NOD2ACVR1 | |
| SCHEMBL16445738 | 0.69 | FGFR1 (0.64) | SRCFGFR1RIPK2NOD2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003745-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009030-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-02-25 | — | — | WO | disclosed |