Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8151400 | 1.00 | SLC6A4 (0.42) | SLC6A4ALDH1A1SMN1; SMN2LMNABLM | |
| SCHEMBL8152267 | 0.83 | SLC6A2 (0.54) | SLC6A4ALDH1A1BLMSLC6A2MAPT | |
| SCHEMBL12362873 | 0.83 | SLC6A2 (0.54) | SLC6A4ALDH1A1BLMSLC6A2MAPT | |
| SCHEMBL8152258 | 0.83 | SLC6A2 (0.54) | SLC6A4ALDH1A1BLMSLC6A2MAPT | |
| SCHEMBL8152263 | 0.83 | SLC6A2 (0.54) | SLC6A4ALDH1A1BLMSLC6A2MAPT | |
| SCHEMBL8158561 | 0.83 | SLC6A2 (0.54) | SLC6A4ALDH1A1BLMSLC6A2MAPT | |
| SCHEMBL7249193 | 0.78 | LTB4R (0.55) | BLMSIGMAR1LTB4RLTB4R2TSHR | |
| SCHEMBL31558346 | 0.78 | LTB4R (0.55) | BLMSIGMAR1LTB4RLTB4R2TSHR | |
| SCHEMBL9422155 | 0.74 | OPRM1 (0.42) | BLMSIGMAR1TSHR | |
| SCHEMBL24821521 | 0.74 | BLM (0.42) | SLC6A4BLMSLC6A2SIGMAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136803-A | CYCLOALKYL ETHER INDANAMINE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 2000-10-24 | — | — | US | disclosed |
| US-5561152-A | 1-PHENOXY-2-(AMINOMETHYL)INDAN DERIVATIVES; ADRENERGIC BLOCKING AGENT; INHIBITORS OF BOTH NOREPINEPHRINE AND SEROTONIN UPTAKE | MERRELL PHARMACEUTICALS INC. (US) | 1996-10-01 | — | — | US | disclosed |
| EP-0303961-B1 | Novel antidepressants | MERRELL DOW PHARMA (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0371508-B1 | PHENOXY AND PHENYLTHIO, AMINO SUBSTITUTED BENZOCYCLOALKANE DERIVATIVES IN THE TREATMENT AND PREVENTION OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-07-14 | — | — | EP | disclosed |
| US-5149714-A | Antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-22 | — | — | US | disclosed |
| US-5134168-A | PHENOXY AND PHENYLTHIO, AMINO SUBSTITUTED BENZOCYCLOALKANE DERIVATIVES IN THE TREATMENT AND PREVENTION OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0371508-A1 | Phenoxy and phenylthio, amino substituted benzocycloalkane derivatives in the treatment and prevention of drug-resistant protozoal infections | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0303961-A2 | Novel antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-02-22 | — | — | EP | disclosed |