Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | PGK2 | P07205 | 1/20 | 0.39 |
| ▸ | PGD | P52209 | 1/20 | 0.36 |
| ▸ | TPI1 | P60174 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 10/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133396 | 0.93 | FBP1 (0.37) | PGK1PGK2TPI1S1PR1S1PR3 | |
| SCHEMBL23777275 | 0.93 | FBP1 (0.37) | PGK1PGK2TPI1S1PR1S1PR3 | |
| Phosphoric Acid SCHEMBL3381220 | 0.91 | S1PR1 (0.36) | PGK1PGK2TPI1S1PR1S1PR3 | |
| Ammonia Solution, Strong SCHEMBL5467104 | 0.91 | S1PR1 (0.36) | PGK1PGK2TPI1S1PR1S1PR3 | |
| Urea SCHEMBL30343660 | 0.89 | PGD (0.38) | PGK1PGK2PGDTPI1S1PR1 | |
| SCHEMBL135753 | 0.88 | FBP1 (0.37) | PGK1PGK2TPI1S1PR1S1PR3 | |
| SCHEMBL9050666 | 0.86 | S1PR1 (0.34) | PGK1PGK2TPI1S1PR1S1PR3 | |
| Methyl Phosphonate SCHEMBL8740593 | 0.86 | S1PR1 (0.37) | S1PR1S1PR3FBP1S1PR4S1PR5 | |
| Hydrochloric Acid SCHEMBL4602688 | 0.86 | S1PR1 (0.36) | PGK1PGK2TPI1S1PR1S1PR3 | |
| Acrylic Acid SCHEMBL5685585 | 0.85 | ALDH1A1 (0.43) | PGK1PGK2PGDS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997044385-A1 | FLAME RETARDANT POLYKETONE COMPOSITION | AKZO NOBEL N.V. (NL) | 1997-11-27 | — | — | WO | claimed |
| WO-1997041173-A1 | FLAME RETARDANT COMPOSITION FOR POLYMERS | AKZO NOBEL N.V. (NL) | 1997-11-06 | — | — | WO | claimed |
| US-5633301-A | OLEFIN-CARBON MONOXIDE COPOLYMER | AKZO NOBEL NV (NL) | 1997-05-27 | — | — | US | claimed |
| EP-0578319-A1 | Process for forming bis(pentaerythritol phosphate) carbonate | Akzo Nobel N.V. (NL) | 1994-01-12 | — | — | EP | claimed |
| US-5235085-A | Reacting pentaerythritol phosphate alcohol with dihydrocarbyl carbonate | AKZO N.V. (NL) | 1993-08-10 | — | — | US | claimed |
| WO-2000012608-A1 | FLAME RESISTANT POLYKETONE RESIN COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 2000-03-09 | — | — | WO | disclosed |
| WO-1997044385-A1 | FLAME RETARDANT POLYKETONE COMPOSITION | AKZO NOBEL N.V. (NL) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997044385-A1 | FLAME RETARDANT POLYKETONE COMPOSITION | AKZO NOBEL N.V. (NL) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997041173-A1 | FLAME RETARDANT COMPOSITION FOR POLYMERS | AKZO NOBEL N.V. (NL) | 1997-11-06 | — | — | WO | disclosed |
| US-5633301-A | OLEFIN-CARBON MONOXIDE COPOLYMER | AKZO NOBEL NV (NL) | 1997-05-27 | — | — | US | disclosed |
| US-5633301-A | OLEFIN-CARBON MONOXIDE COPOLYMER | AKZO NOBEL NV (NL) | 1997-05-27 | — | — | US | disclosed |
| EP-0578319-A1 | Process for forming bis(pentaerythritol phosphate) carbonate | Akzo Nobel N.V. (NL) | 1994-01-12 | — | — | EP | disclosed |
| EP-0578319-A1 | Process for forming bis(pentaerythritol phosphate) carbonate | Akzo Nobel N.V. (NL) | 1994-01-12 | — | — | EP | disclosed |
| US-5235085-A | Reacting pentaerythritol phosphate alcohol with dihydrocarbyl carbonate | AKZO N.V. (NL) | 1993-08-10 | — | — | US | disclosed |
| US-5235085-A | Reacting pentaerythritol phosphate alcohol with dihydrocarbyl carbonate | AKZO N.V. (NL) | 1993-08-10 | — | — | US | disclosed |
| US-5235085-A | Reacting pentaerythritol phosphate alcohol with dihydrocarbyl carbonate | AKZO N.V. (NL) | 1993-08-10 | — | — | US | disclosed |