Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.40 |
| ▸ | AXL known ✓ | P30530 | 1/20 | 0.38 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL905990 | 0.89 | PDPK1 (0.54) | PDPK1JAK2DYRK1ADCLK1PRKD3 | |
| Fumaric Acid SCHEMBL8145083 | 0.86 | BLM (0.46) | NPSR1BLMJAK2DYRK1ASIRT1 | |
| Fumaric Acid SCHEMBL8146172 | 0.84 | HTR1A (0.47) | NPSR1BLMAURKBGSK3BHTR2A | |
| Fumaric Acid SCHEMBL8146164 | 0.84 | HTR1A (0.47) | NPSR1BLMAURKBGSK3BHTR2A | |
| Fumaric Acid SCHEMBL11766217 | 0.78 | JAK2 (0.73) | PDPK1JAK2DYRK1ADCLK1PRKD3 | |
| Maleic Acid SCHEMBL11766203 | 0.78 | JAK2 (0.73) | PDPK1JAK2DYRK1ADCLK1PRKD3 | |
| SCHEMBL7486071 | 0.78 | JAK2 (0.53) | PDPK1JAK2DYRK1ADCLK1PRKD3 | |
| SCHEMBL5987890 | 0.75 | HTR2A (0.55) | NPSR1BLMPDPK1JAK2PMP22 | |
| SCHEMBL8151975 | 0.74 | PDPK1 (0.42) | PDPK1JAK2DYRK1ADCLK1PRKD3 | |
| Hydrochloric Acid SCHEMBL5989450 | 0.74 | HTR1A (0.54) | NPSR1BLMPDPK1JAK2PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000012482-A2 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |