Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | OGA | O60502 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12359539 | 0.85 | DRD2 (0.67) | DRD2DRD4DRD3CYP11B2ALDH1A1 | |
| SCHEMBL1306724 | 0.85 | DRD2 (0.53) | DRD2DRD4DRD3CYP11B2CHRNB4 | |
| SCHEMBL1308298 | 0.83 | DRD2 (0.64) | DRD2DRD4DRD3CYP11B2ALDH1A1 | |
| SCHEMBL19231569 | 0.80 | DRD2 (0.63) | DRD2DRD4DRD3CYP11B2ALDH1A1 | |
| SCHEMBL10245276 | 0.80 | DRD2 (0.63) | DRD2DRD4DRD3CYP11B2ALDH1A1 | |
| SCHEMBL8145351 | 0.79 | OGA (0.59) | ALDH1A1GAAOGAADORA2AADORA1 | |
| SCHEMBL8153002 | 0.78 | CHRNB2 (0.55) | ALDH1A1 | |
| SCHEMBL656126 | 0.78 | DRD2 (0.63) | DRD2DRD4DRD3CYP11B2ALDH1A1 | |
| SCHEMBL19231570 | 0.78 | DRD2 (0.60) | DRD2DRD4DRD3CYP11B2ALDH1A1 | |
| SCHEMBL10339000 | 0.77 | DRD2 (0.66) | DRD2DRD4DRD3ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |