Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8145178 | 0.83 | HDAC1 (0.46) | BRAFZAP70HDAC1CCNT1CDK9 | |
| SCHEMBL8154100 | 0.83 | ZAP70 (0.61) | BRAFZAP70CCNT1CDK9PRKD3 | |
| SCHEMBL8139918 | 0.82 | SYK (0.46) | BRAFZAP70HDAC1CCNT1CDK9 | |
| SCHEMBL8149363 | 0.81 | ZAP70 (0.59) | ZAP70CCNT1CDK9PRKD3EGFR | |
| SCHEMBL8148529 | 0.80 | BRAF (0.45) | BRAFZAP70RAB9AHDAC1NPC1 | |
| SCHEMBL8148183 | 0.74 | HDAC1 (0.53) | RAB9AHDAC1NPC1DGAT1KDM4E | |
| SCHEMBL8146572 | 0.73 | HDAC1 (0.48) | BRAFZAP70RAB9AHDAC1DGAT1 | |
| SCHEMBL8148560 | 0.69 | ZAP70 (0.48) | BRAFZAP70CCNT1CDK9CCNA2 | |
| SCHEMBL13705283 | 0.69 | NPC1 (0.44) | RAB9ANPC1GRIN2B | |
| SCHEMBL8148420 | 0.69 | WNT3A (0.49) | ZAP70CCNT1CDK9CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6093716-A | Substituted 2-pyrimidineamines and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| EP-0929549-A1 | SUBSTITUTED 2-PYRIMIDINEAMINES, THEIR PREPARATION AND THEIR USE AS PROTEINE KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998011095-A1 | SUBSTITUTED 2-PYRIMIDINEAMINES, THEIR PREPARATION AND THEIR USE AS PROTEINE KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-03-19 | — | — | WO | disclosed |